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KMID : 0981420050080020074
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Schizophrenia Clinics
2005 Volume.8 No. 2 p.74 ~ p.79
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Screening of Chromosome 22q11-13 Deletion in Schizophrenia by Array-Comparative Genomic Hybridization
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Moon Ho-Jin
Yim Sung-Vin
Lee Kweon-Haeng
Jeon Yang-Whan
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Abstract
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Objective：Schizophrenia is a complex psychiatric disorder with various etiological factors. Chromosomal aberrations among factors were important contributing factors in schizophrenia. This study was aimed to detect chromosomal abnormality in schizophrenia.
Methods：We have screened 22q11-13 for chromosomal aberrations in 30 patients with schizophrenia by array-comparative genomic hybridization (CGH) and have been able to identify DNA aberration in schizophrenia. To confirm genomic imbalances identified with array-CGH, DNA samples with genomic changes were analyzed real-time PCR.
Results：Main locations of chromosome aberrations indicated in 22q11.2, 22q12.1-2 region. Numbers deleted genomic copy number were 11 cases in 22q11.2 region and 8 cases in 22q12.1-2 region. Also, real-time PCR results were well correspondence with all CGH results.
Conclusion：This study suggest that array-CGH is useful for detection of chromosomal aberrations in schizophrenia. our research could make possible candidate gene approach of schizophrenia and contribute to discover pathogenesis of schizophrenia.
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KEYWORD
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Schizophrenia, Chromosomal aberration, Array-CGH, Real-time PCR
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